Apatinib in refractory radiation-induced brain edema

Apatinib in refractory radiation-induced brain edema

RATIONALE Apatinib is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, which has observed to be effective and safe in refractory radiation-induced brain edema, like Avastin did. Till now, there is no case report after apatinib came in the market. PATIENT CONCERNS Two patients who received brain radiotherapy developed clinical manifestations of brain e...

Apatinib in refractory radiation-induced brain Edema: A case report: Erratum

Efficacy and safety of bevacizumab treatment for refractory brain edema

OBJECTIVE This retrospective study investigated the efficacy and safety of bevacizumab treatment for refractory brain edema. METHODS Between March 2009 and December 2015, bevacizumab was used to treat 59 cases of brain metastatic patients with refractory brain edema. The median dose of bevacizumab was 4.68 mg/kg (range 2.8-6.52 mg/kg). The clinical-pathological data, the efficacy, and the sid...

Refractory Diabetic Macular Edema

Diabetic macular edema (DME) is arguably one of the most important challenges in ophthalmology. Macular edema refractory to laser photocoagulation remains the most prevalent cause of untreatable vision loss in diabetes and is responsible for visual disability in millions of people worldwide. The lack of an effective therapeutic solution accounts for the range of interventions proposed. These in...

Ischemic Brain Edema and Compression Brain Edema

Grades of recovery and outcome of patients with "stroke" have been widely reported by different authors.' There is reasonable agreement on the "poor" outcome of a certain number of surviving "stroke" patients; their number is widely estimated to vary from 19% to 35%. With the growing need for physical medicine and rehabilitation treatment and the associated mushrooming financial expenditures fo...